The method one actually employs depends on what is required from the analysis. Body weight was the best predictor in parameter models for all model parameters cl, q, v1 and v2. Noncompartment model to compartment model pharmacokinetics. Non compartment model to compartment model pharmacokinetics transformation metaanalysis a multivariate nonlinear mixed model. A much more uptodate version of this course is available at basic pharmacokinetics. Chapter 16 non compartmental analysis johan gabrielsson and daniel weiner abstract when analyzing pharmacokinetic data, one generally employs either model. One compartment open model, extravascular administration, firstorder absorption.
Noncompartment pharmacokinetics is a new approach devised to study the time course of drug in the body with out assuming any compartment model. Non compartment model to two compartment model transformation. If neither is possible, it is still possible to exploit the special features of the compartmental equations to give bounds on the values for the rate constants chau. Compartment is the traditional and most widely used approach to pharmacokinetic characterization of drug. These models simply interpolate the instrumental data and allow on empirical formula to. A first course in pharmacokinetics and biopharmaceutics david bourne, ph. This paper proposed an important approach to transform published noncompartment model pharmacokinetics pk parameters into compartment.
Compartmental and noncompartmental pharmacokinetic analysis. A single compartment simulation model of pharmacokinetics. Among the three main types of pharmacokinetic pk models. If a drugs pharmacokinetics follows a two compartment model with oral dose 5, the following non compartment model pk parameters, w vd, auc, t max, cl iv, t 12,slow, t 12,fast, are necessary to recover the two compartment model parameters. This noncompartment model pk parameter transformation into compartment model metaanalysis approach possesses valid. Phar 7633 chapter 21 non linear pharmacokinetic models scheme or diagram diagram 21. In the general case, of noncommensurateorder systems, a different approach. The fundamental principles of compartmental pharmacokinetics.
Basic assumption is that drug or metabolite follows. This paper proposed an important approach to transform published non compartment model pharmacokinetics pk parameters into compartment. Phar 7633 chapter 21 nonlinear pharmacokinetic models. Compartmental and noncompartmental pharmacokinetic. This paper proposed an important approach to transform published noncompartment model pharmacokinetics pk. Compartmental model a compartment is a group of tissues with similar blood flow and drug affinity. A first course in pharmacokinetics and biopharmaceutics. Introduction to noncompartmental pharmacokinetic approach differences between compartment and noncompartment models concepts of noncompartmental model statistical moments theorymean residence time different pharmacokinetic parameters in noncompartment model noncompartment pharmacokinetics is a new approach devised to. Compartmental modeling describes the movement of a substance from one compartment to another. When analyzing pharmacokinetic data, one generally employs either model fitting using nonlinear regression analysis or noncompartmental analysis. Pharmacokinetic data analysis has been increasingly utilized since this approach permits the analysis of data without the use of a specific compartment model.